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Today, a variety of healthy foods are seen in the market while the users increase year by year. Meanwhile, many products doubtful in terms of their safety are sold among them in fact. Foods can have effects on the health of people by intake, and the safety is more critical issue than anything else. Based on the recognition that safety for human health is essential, TAHEEBO JAPAN requested independent and objective testing laboratories to conduct a range of safety studies. The study results have confirmed the safety of “TAHEEBO NFD” as a food.
Study laboratories:Japan SLC, Inc. (Contract Research Department)
http://www.jslc.co.jp
BML, Inc. (Safety Evaluation Department)
http://www.bml.co.jp
Study name Single dose oral toxicity study of Avellanedae extract powder in rats
Study article Avellanedae extract powder
Study objective A dose of Avellanedae extract powder is administered orally in male and female rats, and the acute toxicity is examined.
Study result No death was observed in both male and female groups administered with the study article. The minimum lethal dose exceeded 2000 mg/kg. The changes of body weight were similar to those of the control group. The autopsy of all the specimens revealed no abnormality.
Study laboratory: Japan SLC, Inc. (Contract Research Department)
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Study name Mutagenicity study of Avellanedae extract powder in microorganisms
Study article Avellanedae extract powder (BML-2606)
Study objective Avellanedae extract powder is tested to determine whether it has a mutagenic effect induced by microorganisms.
Study result Avellanedae extract powder is considered to have no mutagenic effect induced by any strains of Salmonella typhimurium (TA100, TA1535, TA98, and TA1537) and Escherichia coli (WP2 uvrA), regardless of whether it is in active metabolic state or not.
Study laboratory: Japan SLC, Inc. (Contract Research Department)
BML, Inc. (Safety Evaluation Department) Study no.: 4329
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Study name Mutagenicity study of Avellanedae extract powder in microorganisms (with adjuvant)
Study article Avellanedae extract powder (BML-4708)
Study objective Avellanedae extract powder is tested to determine whether it has a mutagenic effect induced by microorganisms.
Study result Avellanedae extract powder is considered to have no mutagenic effect.
Study laboratory: Japan SLC, Inc. (Contract Research Department)
BML, Inc. (Safety Evaluation Department) Study no.: 6640
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Study name Chromosome aberration test of Avellanedae extract powder in mammalian cell culture
Study article Avellanedae extract powder (BML-3757)
Study objective Avellanedae extract powder is tested to determine whether it has clastogenic property in mammalian cell culture (CHL/IU cells).
Study result This study was performed based on a pilot test. Any results of the direct method or the metabolic activation method of the study did not indicate a property of Avellanedae extract powder to induce structural or numeric chromosome aberrations. In conclusion, the study article is considered to have no clastogenic property in Chinese hamster lung fibroblast cell line (CHL/IU).
Study laboratory:Japan SLC, Inc. (Contract Research Department)
BML, Inc. (Safety Study Division, Cell Biology Department) Study no.: 5618
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Study objective Avellanedae extract powder is administered in the eyes of young mature rabbits to determine its primary irritation property on eye mucosa, and the results are reported.
Study result The solution of Avellanedae extract powder dissolved in 0.05% physiological saline is considered to have no irritation property on eye mucosa of rabbits.
Study laboratory:Japan SLC, Inc. (Contract Research Department)
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Study objective Avellanedae extract powder is applied on the rabbit skin to determine its primary irritation property on skin, and the results are reported.
Study result The solution of Avellanedae extract powder dissolved in 0.1% acetone was classified as a mild irritant.
Study laboratory: Japan SLC, Inc. (Contract Research Department)
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Study objective Avellanedae extract powder is tested to determine its skin sensitivity in guinea pigs, and the results are reported.
Study result Avellanedae extract powder is considered to have no noticeable level of skin sensitivity in guinea pigs.
Study laboratory: Japan SLC, Inc. (Contract Research Department)
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Study objective Avellanedae extract powder is tested to determine its phototoxicity on the skin of guinea pigs, and the results are reported.
Study result Avellanedae extract powder is considered to have no noticeable level of phototoxicity on the skin of guinea pigs.
Study laboratory: Japan SLC, Inc. (Contract Research Department)
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Study objective Avellanedae extract powder is tested to determine its photosensitizing property in guinea pigs by the Adjuvant and strip method, and the results are reported.
Study result No positive skin reaction was observed in any of the animals photosensitized and photochallenged with Avellanedae extract powder. Avellanedae extract powder is considered to have no photosensitizing property.
Study laboratory:Japan SLC, Inc. (Contract Research Department)
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Study name Study of Avellanedae tea containing indigestible dextrin for the effect on the reduction of blood sugar increase and the safety after long-term intake
Study article Avellanedae tea containing indigestible dextrin
Study objective Avellanedae extract powder containing indigestible dextrin is tested to determine the safety in human after the long-term intake.
Study result Twelve healthy volunteers took Avellanedae extract powder containing indigestible dextrin 3 times a day for 12 weeks, and the physical, blood pressure, and laboratory measurements were performed subsequently. No significant change was observed in the measurements, and the long-term continuous intake did not indicate any clinically relevant problem.
Study laboratory:The article on this study was presented in Journal of
Nutritional Food (2001) vol. 4, no.4.
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“TAHEEBO NFD” originates from the tea brewed from the barks of Tabebuia avellanedae in Brazil. It is a drink for good health taken by local people for more than 1500 years.

We have developed and marketed “TAHEEBO NFD” in Japan for more than 20 years, and have not received any report of its adverse effects on human bodies yet.
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